(023) The Acute Effect of Caffeine on Genital Arousal in Women: A Pilot Study. The Journal of Sexual Medicine, 20(Supplement_2). Crocus sativus (saffron) in the treatment of female sexual dysfunction: A three-center, double-blind, randomized, and placebo-controlled clinical trial. Saffron for treatment of fluoxetine-induced sexual dysfunction sexual tablets for women in women: Randomized double-blind placebo-controlled study. Human Psychopharmacology: Clinical and Experimental, 28(1), 54-60.
Evidence-Based Complementary and Alternative Medicine: ECAM, 7(3), 279. Effectiveness of guaraná (Paullinia cupana) for postradiation fatigue and depression: results of a pilot double-blind randomized study. Journal of Alternative and Complementary Medicine (New York, N.Y.), 15(4), 431–433. Effects of a commercial product containing guaraná on psychological well-being, anxiety and mood: A single-blind, placebo-controlled study in healthy subjects. Journal of Negative Results in Biomedicine, 12, 9. DARU Journal of Pharmaceutical Sciences, 22(1), 40. Tribulus Terrestris for Female Sexual Dysfunction: A Systematic Review. Tribulus terrestris and female reproductive system health: A comprehensive review. Bioavailability enhancers of herbal origin: An overview. Asian Pacific Journal of Tropical Biomedicine, 3(4), 253.
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Fenugreek, A Potent Hypoglycaemic Herb Can Cause Central Hypothyroidism Via Leptin - A Threat To Diabetes Phytotherapy. Experimental and Clinical Endocrinology & Diabetes: Official Journal, German Society of Endocrinology [and] German Diabetes Association, 125(7), 441–448.
Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial. Menopause (New York, N.Y.), 23(11), 1252–1256. A systematic review of clinical trials on Ginkgo (Ginkgo biloba) effectiveness on sexual function and its safety. Journal of ethnopharmacology, 145(3), 715–721. Capsaicinoids Modulating Cardiometabolic Syndrome Risk Factors: Current Perspectives.
The effect of melatonin on the sexual function among postmenopausal women: A randomized placebo-controlled trial. Nursing and Midwifery Studies, 6(4), 149. Understanding Unapproved Use of Approved Drugs "Off Label". Physiologic Measures of Sexual Function in Women: A Review. Topical Pentoxifylline for Pressure Injury Prevention: A Call for Clinical Research.
Advances in skin & Wound Care, 32(11), 486. The effect of topically applied vasoactive agents and testosterone versus testosterone in the treatment of erectile dysfunction in aged men with low sexual interest. International Journal of Impotence Research, 13(2), 93–99. Chemical composition, olfactory evaluation and antioxidant effects of essential oil from Mentha x piperita. Natural Product Communications, 4(8), 1107–1112. Phytoestrogenic effect of fenugreek seed extract helps in ameliorating the leg pain and vasomotor symptoms in postmenopausal women: A randomized, double-blinded, placebo-controlled study. Exploring the Potential of Saffron as a Therapeutic Agent in Depression Treatment: A Comparative Review. The Yale Journal of Biology and Medicine, 97(3), 365. What can you do to increase libido?
Low sex drive affects about 4 in 10 women, increasing in midlife and peaking after menopause. Many things factor into your sexual desire—fluctuating hormone levels, lifestyle habits, mood, underlying health conditions, relationship factors, and more—but there are many ways to improve the situation, especially if menopause-related issues are the root cause. While libido is complex, there are many things you can do to amp things back up. Learn how to increase sex drive, plus libido-boosting supplements for women, relationship help, and more. If you're reading this, you're likely wondering how to reignite your libido—or perhaps you’re simply curious about what might be getting in the way. Maybe you can remember a time when you craved intimacy, when the desire to connect physically felt natural and effortless. But now, rekindling that spark seems elusive, or frankly unappealing if you have symptoms that make it hard to get in the mood (ugh, vaginal dryness). Well, you’ve come to the right place for answers. If low libido has become part of your reality, you’re not alone. A staggering 38% of women in the U.S. report struggling with low sexual desire, according to a comprehensive study in the journal Obstetrics & Gynecology. What's more, as you age, so does the likelihood of diminished libido—by the time women reach 65, three out of four report little to no desire. But here’s some good news: You can turn things around.
Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers. Clitoral blood flow after use of gel containing L-arginine and L-citrulline. Turnera diffusa Wild (Turneraceae) recovers sexual behavior in sexually exhausted males. Journal of Ethnopharmacology, 123(3), 423–429. Hypoactive Sexual Desire Disorder: International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel Review.
Mayo Clinic Proceedings, 92(1), 114–128. Flibanserin for Premenopausal Hypoactive Sexual Desire Disorder: Pooled Analysis of Clinical Trials. Journal of Women's Health (2002), 28(6), 769–777. Melanocortin 4 receptor agonism enhances sexual brain processing in women with hypoactive sexual desire disorder. Peripheral Female Genital Arousal as Assessed by Thermography Following Topical Genital Application of Alprostadil vs Placebo Arousal Gel: A Proof-of-Principle Study Without Visual Sexual Stimulation.
Effect of Diindolylmethane on Estrogen-related Hormones, Metabolites and Tamoxifen Metabolism: Results of a Randomized, Placebo-controlled Trial. Cancer Epidemiology Biomarkers & Prevention 1, 26(3), 435. Flibanserin (Addyi): The First FDA-Approved Treatment for Female Sexual Interest/Arousal Disorder in Premenopausal Women. Role of Nitric Oxide in the Cardiovascular and Renal Systems. International Journal of Molecular Sciences, 19(9), 2605. Many things can make sex less exciting for women throughout life, and especially during menopause, including problems in the areas of desire, arousal, orgasm, and pleasure, says Midi’s chief clinical officer Mindy Goldman, M.D. Unfortunately there are still many societal taboos around discussing sex, says Goldman, making women less likely to bring it up with their doctor. “Women should know that sexual concerns are normal and can be addressed,” says Dr. Goldman. “That’s why it’s especially important to find a provider who is knowledgeable and comfortable and open in discussing these concerns.” So, how can you get your libido back? We’ll break down everything you need to know about low libido, natural ways to increase it, plus medical treatments, relationship fixes, and more. At Midi, our clinicians have heard—and treated it all—so they can help you regain your spark and interest in sex.
| Side Effect | Common Symptoms | Frequency | Severity |
|---|---|---|---|
| Headaches | Mild congestion, headaches | Rarely reported | Mild |
| Digestive Issues | Nausea, stomach upset | Occasionally | Mild to Moderate |
| Allergic Reactions | Rash, swelling | Rare | Variable |
| Insomnia | Difficulty sleeping | Sometimes | Mild |
| Hormonal Imbalance | Irregular cycles | Rare | Moderate |
Libido is simply a word to describe sexual desire, or how much you want to engage in sexual activity. You can have a high libido, meaning you have a high sex drive. You can also have a low libido, which means a low sex drive. During perimenopause and menopause, declining levels of estrogen can take your typical level of desire and tank it. Not to mention that a decrease in estrogen can also cause vaginal dryness and thinning that make sex uncomfortable and painful.
Of course, it’s important to remember that levels of desire are so individual, varies from person-to-person, and can shift throughout life. And then there’s how your low libido can affect your relationship—especially if there’s a mismatch in sex drive with your partner that's putting a real dent in both of your lives. If low libido lingers for a long time, you may be diagnosed with hypoactive sexual desire disorder, or HSDD. HSDD is defined as “a persistent or recurrent absence of sexual fantasies and desire for sexual activity, causing personal distress or interpersonal difficulties.” That last part—personal distress/interpersonal difficulties—is really important.
| Factor | Description | Recommendations |
|---|---|---|
| Ingredient Safety | Ensure ingredients are tested and approved | Look for reputable brands |
| Personal Health Conditions | Check for allergies or contraindications | Consult healthcare provider |
| Effect Duration | How long the effects last | Match with desired timing |
| Onset of Action | How quickly it works | Some work within an hour, others take weeks |
| Price and Accessibility | Affordability and availability | Choose budget-friendly options |
When your low libido is making you feel unhappy or causing issues in your relationship, then it’s something to take steps to treat. (You’re in the right place, keep reading!) The symptoms of low libido can include: Reduced or lack of desire for fantasies and sexual stimulation Inability to maintain desire during sexual activity Loss of desire to initiate or participate in sexual activity Avoidance of situations that can lead to sexual activity Making things more complex are all of the factors that influence your sexual desire, including: Physical causes: Hormonal changes like menopause, which can affect vaginal tissues in particular, leading to discomfort; stage of life, such as postpartum; medications; and underlying medical conditions like thyroid disease.
Systematic review and meta-analysis of phosphodiesterase type 5 inhibitors for the treatment of female sexual dysfunction. International Journal of Gynecology & Obstetrics, 133(2), 139-145. Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial. (308) Oxytocin Troches as an Adjunctive Intervention to Conventional Testosterone and Erectile Dysfunction Medication for Men with Sexuality Concerns. The Journal of Sexual Medicine, 20(Supplement_1).
Tadalafil once daily: Narrative review of a treatment option for female sexual dysfunctions (FSD) in midlife and older women. Tadalafil reversal of sexual dysfunction caused by serotonin enhancing medications in women. Journal of Sex & Marital Therapy, 32(1), 1–3. Tadalafil 5 mg Daily Treatment for Type 1 Diabetic Premenopausal Women Affected by Sexual Genital Arousal Disorder. The Journal of Sexual Medicine, 9(8), 2057-2065.
Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study. Safety and influence of a novel extract of fenugreek on healthy young women: A randomized, double-blinded, placebo-controlled study. Evaluation of aphrodisiac activity of ethanol extract of Ganoderma lucidum in male Wistar rats. Translational Andrology and Urology, 11(7), 982. Guaraná's Journey from Regional Tonic to Aphrodisiac and Global Energy Drink.