Long-Term Safety Profile of Tadalafil in Female Patients
This medicine can cause serious side effects in patients with heart problems.
What other drugs will affect tadalafil?
Chewable tablets: Chew the tablet completely before swallowing. When using this medicine for erectile dysfunction, the ability to have sexual activity may be improved for up to 36 hours after taking the tablet. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way. Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Table 2.
Grapefruit and grapefruit juice may change the amount of this medicine that is absorbed in the body. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
Common side effects
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets):For treatment of benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) as a single dose, no more than once a day, taken at the same time each day.Children—Use is not recommended.For treatment of erectile dysfunction (as needed):Adults—10 milligrams (mg) as a single dose, no more than once a day, taken 30 minutes before you think sexual activity may occur. Your doctor may adjust your dose as needed.Children—Use is not recommended.For treatment of erectile dysfunction (daily use):Adults—2.5 milligrams (mg) once a day, taken at the same time each day, without regard for the timing of sexual activity. Your doctor may adjust your dose as needed.Children—Use is not recommended.For treatment of erectile dysfunction and benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) once a day, taken at the same time each day, without regard for the timing of sexual activity.Children—Use is not recommended.For treatment of pulmonary arterial hypertension:Adults—40 milligrams (mg) (two 20 mg tablets) taken once a day. Do not use this medicine if you are also using riociguat (Adempas®) or a nitrate medicine, often used to treat angina (chest pain).
| Drug/Substance | Interaction Type | Effect |
|---|---|---|
| Nitrates | Severe hypotension risk | Avoid concomitant use |
| CYP3A4 Inhibitors | Increased tadalafil levels | Dose adjustment needed |
| Alpha-blockers | Orthostatic hypotension | Monitor blood pressure |
| Grapefruit Juice | CYP3A4 inhibition | Potentially increased drug effect |
Some illegal ("street") drugs called "poppers" (such as amyl nitrate, butyl nitrate, or nitrite) also contain nitrates.
- Tadalafil can help treat female sexual dysfunction linked to vascular issues.
- Some women report improved arousal and sensation with tadalafil.
- The drug’s safety profile in women is not fully established.
- Tadalafil is sometimes used in research for postpartum sexual health.
- Women should avoid alcohol when taking tadalafil.
- It is available via prescription in some countries for research.
- Use of tadalafil should be under medical supervision.
- Tadalafil may cause nasal congestion in women.
- Further studies are required for clear guidelines.
If you need to use a nitrate medicine, take it at least 48 hours after your last dose of tadalafil.
| Use | Description | Evidence Level |
|---|---|---|
| Female Sexual Dysfunction | To improve libido and arousal | Experimental, some positive reports |
| Vestibular Disorders | To enhance blood flow in inner ear | Limited data |
| Pulmonary Hypertension | To reduce pulmonary artery pressure | Off-label, under clinical study |
Do not drink excessive amounts of alcohol (eg, 5 or more glasses of wine or 5 or more shots of whiskey) when taking tadalafil. When taken in excess, alcohol can increase your chances of getting a headache or dizziness, increase your heart rate, or lower your blood pressure.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Cialis Generic | 60mg | 360 + 10 Pills | 570.52€ 543.35€ | |
| Cialis Generic | 10mg | 20 Pills | 48.23€ 45.93€ | |
| Cialis Generic | 5mg | 120 + 6 Pills | 132.92€ 126.59€ | |
| Cialis Generic | 5mg | 270 + 10 Pills | 205.81€ 196.01€ | |
| Cialis Generic | 20mg | 360 + 10 Pills | 427.34€ 406.99€ | |
| Cialis Generic | 5mg | 20 Pills | 41.99€ 39.99€ | |
| Tadalista Super Active | 20mg | 120 + 16 Pills | 382.15€ 363.95€ | |
| Cialis Generic | 60mg | 60 + 4 Pills | 145.06€ 138.15€ | |
| Cialis Generic | 2.5mg | 60 + 4 Pills | 83.43€ 79.46€ | |
| Cialis Generic | 2.5mg | 180 + 10 Pills | 154.86€ 147.49€ | |
| Cialis Generic | 10mg | 90 + 6 Pills | 146.17€ 139.21€ | |
| Cialis Generic | 10mg | 60 + 6 Pills | 105.81€ 100.77€ | |
| Cialis Generic | 2.5mg | 90 + 6 Pills | 112.43€ 107.08€ | |
| Cialis Generic | 10mg | 30 + 4 Pills | 63.32€ 60.30€ | |
| Cialis Generic | 60mg | 120 + 8 Pills | 240.18€ 228.74€ | |
| Cialis Generic | 5mg | 360 + 10 Pills | 268.08€ 255.31€ | |
| Cialis Generic | 20mg | 30 + 4 Pills | 68.05€ 64.81€ |
If you experience sudden loss of vision in one or both eyes, contact your doctor immediately.
Study Design
May increase risk of unwanted side effects (eg, prolonged erection of the penis). Crowded optic disc or low cup to disc ratio in the eye (an eye disorder) or Hyperlipidemia (high lipids or fats in the blood) or Non-arteritic anterior ischemic optic neuropathy or NAION (serious eye condition), history of or May increase risk for non–arteritic anterior ischemic optic neuropathy (NAION). Blood vessel problems (eg, aortic stenosis, idiopathic subaortic stenosis) or Heart attack (within the last 3 months) or Heart failure (within the last 6 months) or Retinitis pigmentosa (an inherited eye disorder) or Stroke (within the last 6 months)—Should not be used in patients with these conditions. Stomach ulcers—Use must be determined by your doctor. Pulmonary veno-occlusive disease or PVOD (a type of lung disease)—Use with caution.
Missed Dose
Liver disease, mild or moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body. Use tadalafil exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking first with your doctor.
Regulatory considerations
This medicine comes with a patient information leaflet. Read it again each time you refill your prescription in case there is new information. Ask your doctor if you have any questions. You may take this medicine with or without food. Do not split, break, chew, or crush it. Check with your doctor right away if you have a sudden decrease in hearing or loss of hearing, which may be accompanied by dizziness and ringing in the ears.
Cialis in Women: Effectiveness & Dosage
Take both tablets at the same time each day. Your doctor may adjust your dose as needed.Children—Use and dose must be determined by your doctor. For treatment of benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) as a single dose, no more than once a day, taken at the same time each day.Children—Use is not recommended. Adults—5 milligrams (mg) as a single dose, no more than once a day, taken at the same time each day. For treatment of erectile dysfunction (as needed):Adults—10 milligrams (mg) as a single dose, no more than once a day, taken 30 minutes before you think sexual activity may occur.
Drug Interactions
Your doctor may adjust your dose as needed.Children—Use is not recommended. Adults—10 milligrams (mg) as a single dose, no more than once a day, taken 30 minutes before you think sexual activity may occur. Your doctor may adjust your dose as needed. For treatment of erectile dysfunction (daily use):Adults—2.5 milligrams (mg) once a day, taken at the same time each day, without regard for the timing of sexual activity. Adults—2.5 milligrams (mg) once a day, taken at the same time each day, without regard for the timing of sexual activity.
Safe dosages
For treatment of erectile dysfunction and benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) once a day, taken at the same time each day, without regard for the timing of sexual activity.Children—Use is not recommended. Adults—5 milligrams (mg) tadalafil 40mg once a day, taken at the same time each day, without regard for the timing of sexual activity. For treatment of pulmonary arterial hypertension:Adults—40 milligrams (mg) (two 20 mg tablets) taken once a day. Adults—40 milligrams (mg) (two 20 mg tablets) taken once a day. Children—Use and dose must be determined by your doctor. Do not take other medicines unless they have been discussed with your doctor.
- Tadalafil has been studied for use in women with diabetic sexual dysfunction.
- Some reports suggest improved functionality with daily use.
- It is being evaluated for postpartum sexual health issues.
- Female-specific studies include subjective sexual satisfaction assessments.
- Tadalafil's use in women remains an off-label option.
- Side effects in women tend to be mild but should be monitored.
- It may benefit women experiencing vaginal dryness due to blood flow issues.
- Weekly or as-needed dosing strategies are under investigation.
- Women interested should seek specialized medical advice.
This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
What should I do in case of overdose?
If you will be taking this medicine for pulmonary arterial hypertension, it is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects. If you take tadalafil for pulmonary arterial hypertension, do not take Cialis® or other PDE5 inhibitors, including sildenafil (Revatio® or Viagra®) or vardenafil (Levitra®). If you take too much tadalafil or take it together with these medicines, the chance for side effects will be higher. Along with its needed effects, a medicine may cause some unwanted effects.
- Tadalafil is being researched to treat female sexual desire disorder.
- It acts by increasing blood flow to genital tissues.
- Efficacy results are mixed and require further investigation.
- It is available under strict medical supervision in trials.
- Side effects in women include headaches and flushing.
- Some studies suggest benefits for postmenopausal women.
- It is not approved for general use in female sexual dysfunction.
- Women should always consult healthcare providers before trying.
- Its future depends on ongoing scientific validation.
Although not all of these side effects may occur, if they do occur they may need medical attention.
How should this medicine be used?
For treatment of benign prostatic hyperplasia (daily use): For oral dosage form (chewable tablet):For treatment of benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) once a day, taken at about the same time each day. Your doctor may adjust your dose as needed.Children—Use is not recommended.For treatment of erectile dysfunction (as needed):Adults—10 milligrams (mg) as a single dose, no more than once a day, taken 30 minutes before you think sexual activity may occur. Your doctor may adjust your dose as needed.Children—Use is not recommended.For treatment of erectile dysfunction and benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) once a day, taken at about the same time each day, without regard for the timing of sexual activity.Children—Use is not recommended. For treatment of benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) once a day, taken at about the same time each day. Adults—5 milligrams (mg) once a day, taken at about the same time each day.
Tadalafil for female sexual dysfunction
For treatment of erectile dysfunction and benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) once a day, taken at about the same time each day, without regard for the timing of sexual activity.Children—Use is not recommended. Adults—5 milligrams (mg) once a day, taken at about the same time each day, without regard for the timing of sexual activity. For treatment of benign prostatic hyperplasia (daily use): If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Should you use tadalafil for muscle growth?
Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. It is important that you tell all of your doctors that you take tadalafil. If you need emergency medical care for a heart problem, it is important that your doctor knows when you last took tadalafil. Check with your doctor immediately if any of the following side effects occur: faintness or lightheadedness when getting up suddenly from a lying or sitting position pain or
- Tadalafil generally takes about 30-60 minutes to work in women.
- Its effects can last up to 36 hours, providing flexibility.
- It is not a standard treatment but a research tool in women.
- The drug is often compared to sildenafil in studies.
- Women should avoid heavy meals before taking tadalafil.
- Proper hydration may improve its effectiveness.
- Women with hypertension should consult a doctor before use.
- Tadalafil may cause visual disturbances in rare cases.
- Its safety profile in women continues to be studied.
discomfort in the arms, jaw, back, or neck Painful or prolonged erection of the penis blistering, peeling, or loosening of the skin fast, irregular, pounding, or racing heartbeat or
What other information should I know?
If you experience a prolonged erection for more than 4 hours or a painful erection for more than 6 hours, contact your doctor immediately. This condition may require prompt medical treatment to prevent serious and permanent damage to your penis. This medicine does not protect you against sexually transmitted diseases (including HIV or AIDS). Use protective measures and ask your doctor if you have any questions about this. It is important to tell your doctor about any heart problems you have now or may have had in the past. pulse inability to move the arms, legs, or facial muscles numbness or tingling of the face, hands, or feet red skin lesions, often with a purple center sores, ulcers, or white spots in the mouth or on the lips swelling of the feet or lower legs Some side effects may occur that usually do not need medical attention.
| Aspect | Feedback from Users | Common Concerns |
|---|---|---|
| Efficacy | Some report improved sexual satisfaction | Mixed results, placebo effect possible |
| Side effects | Mild headaches, flushing reported | Worry about adverse effects |
| Accessibility | Often limited to trials or off-label use | Cost and regulation issues |
| Desire for more research | Strong demand for more data | Lack of official approval |
