Our full guide to L-arginine and erectile dysfunction goes into more detail about how L-arginine works within the body, as well as its potential effects on erectile health.
Although L-arginine may offer some performance benefits, there’s very little clinical research to suggest it has significant effects on erections, bedroom performance, or general sexual desire. Virectin contains L-arginine, tongkat ali, vitamin B3 (niacin), and selenium. It promises to support healthy testosterone levels, boost libido, and enhance drive during sexual activity. Some of the active ingredients in Virectin may offer mild benefits. But there isn’t any high-quality evidence to suggest it improves sexual arousal or treats issues like erectile dysfunction.
And the vitamins — while nice — aren’t a treatment for ED. Marketed as the world’s “leading male-enhancement product,” VigRX Plus contains red ginseng, saw palmetto, ginkgo biloba, and other ingredients alleged to stimulate sexual activity and help maintain a firm erection. In one study published in the journal BMC Complementary and Alternative Medicine, researchers found that the herbal product was more effective than a placebo in improving sexual function in men. However, there’s currently no reliable, high-quality research comparing VigRX to established medications for ED, like sildenafil or other PDE5 inhibitors. We mentioned that over-the-counter Viagra and other OTC ED pills aren’t regulated by the FDA in the same way as prescription medications and why that’s potentially dangerous. Pycnogenol is a nutritional supplement derived from French maritime pine bark extract. It may offer similar benefits for erectile dysfunction. In fact, pycnogenol and L-arginine are sometimes used together in natural supplements for ED. A study from 2003 looked into the effects of L-arginine and pycnogenol as a combined treatment for erectile dysfunction and found they promoted improvements in sexual function after three months of use. By the end of the three-month study, 92.5 percent of participants had experienced a normal erection. These are good signs for sure, but we’re far from establishing a definitive case for pycnogenol. Yohimbe is a tree native to Central and Western Africa. Its bark contains yohimbe, an alleged traditional aphrodisiac.
Though scientific research on yohimbe and erectile dysfunction is mixed overall, some studies have found that it may offer benefits for men with sexual performance issues. For example, a recent review published in the Turkish Journal of Urology used data from eight studies. It found that yohimbine — the active ingredient in yohimbe — was associated with improved erectile function when used in combination with other treatments. But the researchers also noted that yohimbe wasn’t fully effective as a treatment for male sexual function issues when used on its own. Propionyl-L-carnitine, or PLC, is a natural supplement widely promoted for its potential to increase energy levels.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 25mg | 20 Pills | 37.74€ 35.94€ | |
| Kamagra | 100mg | 180 + 6 Pills | 436.79€ 415.99€ | |
| Kamagra Polo | 100mg | 60 + 4 Pills | 189.39€ 180.37€ | |
| Viagra Generic | 100mg | 10 Pills | 28.91€ 27.53€ | |
| Viagra Generic | 100mg | 60 + 4 Pills | 96.36€ 91.77€ | |
| Kamagra Soft Tabs | 100mg | 120 + 6 Pills | 311.78€ 296.93€ | |
| Kamagra | 100mg | 120 + 6 Pills | 330.74€ 314.99€ | |
| Viagra Generic | 150mg | 20 Pills | 55.02€ 52.40€ | |
| Viagra Generic | 100mg | 180 + 8 Pills | 199.37€ 189.88€ | |
| Viagra Generic | 150mg | 270 + 10 Pills | 326.61€ 311.06€ | |
| Viagra Generic | 50mg | 90 + 6 Pills | 107.37€ 102.26€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ | |
| Kamagra Soft Tabs | 100mg | 32 Pills | 120.11€ 114.39€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Viagra Generic | 150mg | 180 + 10 Pills | 236.46€ 225.20€ | |
| Viagra Generic | 200mg | 270 + 10 Pills | 379.76€ 361.68€ | |
| Viagra Generic | 100mg | 90 + 6 Pills | 129.02€ 122.88€ |
While research on propionyl-L-carnitine on its own isn’t conclusive, several studies suggest it may offer benefits for erectile function when used with ED medications. For instance, one study published in the journal Current Medical Research and Opinion found that men with ED — and diabetes — showed larger improvements with propionyl-L-carnitine and sildenafil (the active ingredient in Viagra) than with sildenafil alone.
| Side Effect | Severity | Likelihood | Management Tips | Notes |
|---|---|---|---|---|
| Headache | Mild | Common | Hydration, pain relief | Usually temporary |
| Dizziness | Mild | Common | Sit or lie down slowly | Avoid driving after use |
| Flushing | Mild | Common | Cool down measures | Transient |
| Nasal Congestion | Mild | Sometimes | Decongestants | Usually mild |
| Visual Disturbance | Mild | Rare | Discontinue if persists | Usually reversible |
However, as noted, diabetes was a pre-existing condition for study participants. Additionally, they had already unsuccessfully tried sildenafil by itself.
Now, let’s talk about specific products. Over the years, the FDA has issued numerous health warnings about tainted male enhancement pills. In fact, the government agency posted so many warnings that it maintains a large online database of tainted sexual enhancement products. Products and brands on the list include: It’s best to steer clear of these and go with safer, evidence-backed products for ED. What is it about these products that made the FDA issue a health warning?
For many, it was a problem with the purity or safety of the ingredients. Man Up Now is made with sulfoaildenafil, a synthetic chemical similar to Viagra’s active ingredient, sildenafil. An FDA notice against ExtenZe states that the company’s products have been found to contain undeclared amounts of sildenafil. Vimax is another popular supplement for treating erectile dysfunction and other forms of male sexual dysfunction. It’s marketed as a “100% natural product” containing herbal ingredients for enhancing male virility. So there’s no way to know if these results would be replicated in a larger trial with otherwise healthy participants.
| Product Type | Price Range (USD) | Cost per Dose | Variability Factors | Notes |
|---|---|---|---|---|
| Generic Sildenafil Tablets | $10 - $30 per pack | $1 - $3 | Brand, dosage, retailer | Common OTC option |
| Sildenafil Oral Jelly | $15 - $40 | $2 - $4 | Flavors, brand | Convenient, portable |
| Sildenafil Combinations | $20 - $50 | $2.50 - $5 | Multi-ingredient formulations | Higher cost, multiple benefits |
Other supplements that may help increase blood flow and improve sexual function include: Though these remedies may have some promise, it’s important to keep in mind that they aren’t evidence-based medications — nor are they approved by the FDA to treat any type of disease. This means they haven’t been thoroughly tested for efficacy and safety like FDA-approved drugs have.
The FDA says Viagra works and that dietary supplements may or may not. What are you going to do with this information?
While over-the-counter alternatives to Viagra might seem appealing, you’ll get better results — and keep yourself safer — by working with a healthcare provider to find the right medication. If you have erectile dysfunction caused by a physical health issue, using ED medication to improve your erections might be the best option. These medications work by increasing blood flow to the penis, which can make it easier to get and maintain an erection when you’re sexually aroused.
| Ingredient | Purpose | Typical Dosage | Additional Components |
|---|---|---|---|
| Sildenafil Citrate | Active PDE5 inhibitor | varies (25-100 mg) | None |
| L-Arginine | Supports nitric oxide production | 50-200 mg | Often included for enhanced effect |
| Ginseng Extract | Boosts libido | 100-200 mg | Traditional herbal supplement |
| Yohimbine | Improves blood flow | 5-10 mg | Some products combine with sildenafil |
| Vitamins (e.g., B12) | Overall circulation health | Varies | Often added in formulations |
Currently, there are several safe and effective FDA-approved medications for treating ED. With a prescription from a medical professional, you can purchase oral ED drugs, such as: Most of these medications are taken as needed before sex.
Some particular compounds have been shown to improve blood flow and more, including: Want to see what research has to say about them? Dehydroepiandrosterone, or DHEA, is a hormone produced sildenafil citrate tablets 200mg by the adrenal cortex. It’s an important precursor for several sex hormones, including testosterone. DHEA appears to decline with age, with low levels linked with an elevated risk of erectile dysfunction. Although research findings are inconclusive right now, some studies suggest DHEA may affect receptors that manage blood flow to the penis.
However, there isn’t yet a clear link between DHEA supplementation and improved erections or sexual performance. Next up on the “Might Work to Help You Get Hard But Probably Not” list is L-arginine. This amino acid is purported to help boost nitric oxide production. Nitric oxide helps relax smooth muscles in the arteries that supply blood to the penis, so it plays a major role in producing erections. A meta-analysis published in the Journal of Sexual Medicine looked at 10 randomized controlled trials and found that arginine supplements might provide benefits for men with mild to moderate ED. But tadalafil (Cialis) can be used daily to improve erectile function over the long term. There’s also a prescription injectable medication called alprostadil that’s approved by the FDA for ED. Other compounded medications for ED include BiMix, TriMix, and QuadMix. Eroxon is a recently FDA-authorized topical gel for ED that’s available over the counter.
Magic Male Enhancer take the product off the market. Its two main ingredients — illegal sildenafil and sulfoaildenafil — weren’t declared on the list of ingredients. All PDE5 inhibitors currently available to treat erectile dysfunction can cause interactions when used with medications for hypertension and some heart conditions, such as a sudden drop in blood pressure. To be sure, these issues can also happen with FDA-approved, legally prescribed medications in some cases. But you typically learn about the risks when you speak to a healthcare provider before getting a prescription.
Your healthcare provider can prevent dangerous drug interactions. And unlike the “swallow-it-all” packets the mini-mart attendant hands you, prescriptions are appropriately dosed for patients. So if you’re considering an “all-natural” over-the-counter alternative to Viagra, our recommendation would be to reconsider. Men turn to several herbal supplements and natural remedies for ED, better erections, and elevated sexual function. But we have to caution you that the research on the benefits of natural ED treatments is mixed at best. It’s rubbed on the head of the penis and stimulates nerves to cause an erection. We offer several ED medications on our online platform, following a consultation with a licensed healthcare provider.
But like many over-the-counter ED products, Vimax also contains substances not listed on its label, namely prescription ED medications. In a 2015 notification, the FDA warned consumers that Vimax illegally contains tadalafil, the active ingredient in the ED med Cialis®. Tadalafil can interact with many common medications for treating high blood pressure and chest pain. If you’ve previously had a heart attack or another cardiovascular event, you shouldn’t use it at all without discussing it with a healthcare provider. Because of these risks, it’s best to avoid any supplements containing unlabeled ingredients and instead stick to proven, FDA-approved treatments prescribed by healthcare professionals.
Some over-the-counter erectile dysfunction pills contain more than one active ingredient. This means they may have a higher risk of causing side effects or drug interactions. Others contain unsafe, poorly measured doses of active ingredients. With some OTC erection pills, potentially harmful ingredients aren’t just improperly listed on the product labels, but they’re often used in unsafe doses. For instance, the FDA demanded that the manufacturers of Mr. This allows you to quickly and easily access discreetly packaged, FDA-approved medications for ED from home without any awkward visits to your primary care provider’s office.