Proper Storage for Maintaining Blue Sildenafil Potency

This increased blood flow can cause an erection.

Condition	Risk Factors	Recommendations
Nitrate medication use	Severe hypotension	Do not combine
Uncontrolled hypertension	Cardiovascular risk	Use with caution
Severe liver impairment	Altered drug metabolism	Consult healthcare provider
Retinal disorders	Potential worsening of symptoms	Use only under medical supervision

Sildenafil treats PAH by relaxing the blood vessels

• The pill is often packaged with desiccant to keep it dry and potent.
• It can cause increased sensitivity to touch or skin redness.
• The medication is not recommended for men with unstable angina.
• It is important to avoid taking it with other erectile dysfunction aids.
• The blue color is consistent to help patients avoid taking wrong medication.
• Patients with severe vision problems should discuss risks with their doctor.
• A follow-up appointment is crucial to evaluate the treatment's effectiveness.

in the lungs to allow blood to flow easily.

Detection in biological fluids

Birch DG, Toler SM, Swanson WH, Fish GE, Laties AM . A double-blind placebo-controlled evaluation of the acute effects of sildenafil citrate (Viagra) on visual function in subjects with early-stage age-related macular degeneration. Effect of sildenafil citrate on retinal functions: Preliminary report on Humphrey visual field analysis. The authors have no financial interest with any of the material used in this study Dündar, S., Topaloǧlu, A., Dündar, M. et al.

How it works for PAH

Effects of sildenafil on blue-on-yellow and white-on-white Humphrey perimetry in 3 months regular use. Response to Tomsak, R. PDE5 inhibitors and permanent visual loss (Int J Impot Res 2005; 17: 547–549) International Journal of Impotence Research (2006) take any medicines called nitrates, often prescribed for chest pain, or guanylate cyclase stimulators like Adempas® (riociguat) for pulmonary hypertension. Your blood pressure could drop to an unsafe level are allergic to sildenafil, as contained in VIAGRA and Revatio®, or any of the ingredients in VIAGRA Discuss your health with your doctor to ensure that you are sildenafil 100mg blue pill healthy enough for sex. If you experience chest pain, dizziness, or nausea during sex, seek immediate medical help. If you are taking sildenafil

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to treat erectile dysfunction, you should

Is Viagra approved for women?

If it is not treated right away, priapism can permanently damage your penis sudden vision loss in one or both eyes. Stop taking VIAGRA and call your healthcare provider right away if you have any sudden vision loss Some people may also have ringing in their ears (tinnitus) or dizziness. If you have these symptoms, stop taking VIAGRA and contact a doctor right away Before you take VIAGRA, tell your healthcare provider if you: have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve, or heart failure have had heart surgery within the last 6 months have low blood pressure, or high blood pressure that is not controlled have had an erection that lasted for more than 4 hours have problems with your blood cells such as sickle cell anemia, multiple myeloma, or leukemia have retinitis pigmentosa, a rare genetic (runs in families) eye disease have ever had severe vision loss, including an eye problem called NAION have kidney problems or are having kidney dialysis Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. VIAGRA may affect the way other medicines work, and other medicines may affect the way VIAGRA works, causing side effects. In some patients, the use of VIAGRA with alpha-blockers can lead to a drop in blood pressure or to fainting medicines called HIV protease inhibitors, such as ritonavir (Norvir®), indinavir sulfate (Crixivan®), saquinavir (Fortovase® or Invirase®), or atazanavir sulfate (Reyataz®) some types of oral antifungal medicines, such as ketoconazole (Nizoral®) and itraconazole (Sporanox®) some types of antibiotics, such as clarithromycin (Biaxin®), telithromycin (Ketek®), or erythromycin other medicines that treat high blood pressure VIAGRA contains sildenafil, which is the same medicine found in another drug called REVATIO.

Does Viagra help me keep an erection after ejaculation?

REVATIO is used to treat a rare disease called pulmonary arterial hypertension (PAH). VIAGRA should not be used with REVATIO or with other PAH treatments containing sildenafil or any other PDE5 inhibitors (such as Adcirca® [tadalafil]) VIAGRA does not protect against sexually transmitted diseases, including HIV. The most common side effects of VIAGRA: headache; flushing; upset stomach; abnormal vision, such as changes in color vision (such as having a blue color tinge) and blurred vision; stuffy or runny nose; back pain; muscle pain; nausea; dizziness; rash. VIAGRA, REVATIO, and CARDURA are registered trademarks of Viatris Specialty LLC, a Viatris Company. All other trademarks are the property of their respective owners. know that it does not cure

WHY is this medicine prescribed?

Phase I investigator-blind, placebo-controlled, evaluation of safety, toleration and pharmacokinetics of sildenafil following escalating single oral doses in healthy male volunteers: Study 148-004. In: Viagra(R) (sildenafil): Joint Clinical Review for NDA-20-895. Food and Drug Administration: Washington, 1998, pp 96–98. A double-blind, randomised, placebo-controlled, four-period crossover study to assess the effect of orally administered sildenafil (50, 100, and 200 mg) on visual function in healthy male volunteers. Food and Drug Administration: Washington, 1998, pp 160–161.

How it works for ED

A Double-blind, randomised, placebo-controlled, four-period crossover pilot study to investigate the effects of a single oral tablet dose of sildenafil (200 mg) on visual function (electroretinogram, photostress, visual field and colour discrimination tests) in healthy male volunteers and patients with diabetic retinopathy. Food and Drug Administration: Washington, 1998, pp 177–178. Zrenner E, Koppiker NP, Smith MD, Constable I, Littlewood R, Stuckey B . The effects of long-term sildenafil treatment on ocular safety in patients with erectile dysfunction. Acute effects of sildenafil (Viagra) on blue-on-yellow and white-on-white Humphrey perimetry. erectile dysfunction or increase sexual desire.

Stronger erections, better sex

Click a letter to see a list of drugs beginning with that letter. Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Liqrev, Revatio) is used to improve the ability to exercise in adults (Liqrev, Revatio) and children 1 year of age and older (Revatio) with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Sildenafil is in a class of medications called phosphodiesterase (PDE) inhibitors. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation. Sildenafil does not prevent pregnancy or the spread of

Sildenafil (Viagra) contraindications

Division of Cardio-renal Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration: Washington, DC, 1998, pp 19–21. Animal pharmacology: mechanism of action, section 4.2. In: Viagra (sildenafil): Joint Clinical Review for NDA-20-895. Center for Drug Evaluation and Research, Food and Drug Administration: Washington, DC, 1998, p 4. Acute effects of sildenafil on the electroretinogram and multifocal electroretinogram.

What happens with ED?

Sildenafil causes a dose- and time-dependent downregulation of phosphodiesterase type 6 expression in the rat retina. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A . The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM et al. Sildenafil: an orally type 5 cyclic GMP-spesific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. sexually transmitted diseases such

Age Group	Recommended Dose	Max Dose per Day	Notes
18-65 years	50-100 mg	100 mg	Take 1 hour before activity
Over 65 years	25-50 mg	50 mg	Adjust for health conditions
Patients with liver impairment	25-50 mg	50 mg	Consult doctor prior to use

as human immunodeficiency virus (HIV).

Does Viagra make you last longer?

Currently, beraprost is the only available treatment approved for PAH by Indonesia’s national formulary. Local clinicians regard sildenafil as clinically more effective than beraprost. However, sildenafil is not listed in the national drugs formulary due to pharmaceutical companies’ non-registration of the product for the PAH indication. 20 mg, for PAH indication is also not available in Indonesia Additionally, it is not included in the Indonesian benefits package of Jaminan Kasehatan Nasional (JKN). To investigate its practical use in the Indonesian context, Indonesia’s Health Technology Assessment (HTA) Committee had commissioned a team to conduct a model-based economic evaluation and a budget impact analysis for using sildenafil as a first line treatment for PAH patients.

Recreational use

This study was completed in the last quarter of 2015. There are reports that the government is considering allowing access to sildenafil for PAH through a Special Access Scheme. In this effort, the Health Intervention and Technology Assessment Project (HITAP) Thailand, on behalf of the International Decision Support Initiative (iDSI) provided technical support to the team conducting the study. By embarking on this study, there is hope to providing better access to medicines in the country. We would like to acknowledge the Access and Delivery Partnership (ADP) for their support. Sildenafil comes as a tablet and suspension (liquid) to take by mouth.

Author information

Viagra® (sildenafil citrate) is prescription medicine used to treat erectile dysfunction (ED). VIAGRA is not for women or children. Please see Full Prescribing Information and Patient Information. Pulmonary Arterial Hypertension (PAH) is a life-threatening condition that makes it harder white sildenafil tablets for blood to flow due to narrow or blocked arteries. As a result, the heart has to work harder to pump blood, which eventually makes it weaker and increases the risk of heart failure.

Erectile dysfunction

Incidentally, the drug sildenafil, originally tested for heart problems on the basis of its vasodilatory effects (which widens the blood vessels), can become a treatment for PAH patients. Despite its original intentions, in its first decade (1998-2008), the focus of the drug shifted from treating angina (chest pain), of which the treatment outcome was not satisfactory, to treating erectile dysfunction. As such, it became one of the most commercially successful drugs in the world. Its commercial successes did not incentivize companies to also register it for the indication to treat PAH despite many subsequent experiments, studies, randomized controlled trials, and clinician reports that say the little blue pill may actually be a good if not better treatment for PAH relative to other drugs. In the case of Indonesia, an estimated number of 500 cases of PAH were reported in 2015. If you are taking sildenafil to treat erectile dysfunction,

• The medication is metabolized primarily in the liver by cytochrome P450 enzymes.
• Patients with Peyronie's disease or anatomical deformities should use caution.
• It is not intended for continuous daily use like some other ED medications.
• The average time to peak plasma concentration is about 60 minutes.
• Can be part of a comprehensive treatment plan including lifestyle changes.
• The blue dye used is usually FD&C Blue No. 2 or a similar approved colorant.
• It is important to have realistic expectations about the medication's effects.

follow your doctor's directions and the guidelines in this paragraph.

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